Product Information
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产品货号
BD-PA0002
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别名
PKBB; PRKBB; PKBBETA; RAC-BETA
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产品名称
AKT2 Mouse Monoclonal Antibody
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类别
Antigen Antibody
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基因名称
AKT2
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Clonality
Monoclonal
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推荐应用
WB,IHC-P,ICC,Elisa
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反应种属
Human,Rat,Monkey
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
208
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免疫原
Purified recombinant fragment of human AKT2 expressed in E. Coli.
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稀释度
WB 1:500-1:2000, IHC-P 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:10000
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参考分子量
60kDa
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运输及保存条件
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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宿主
Mouse
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同种型
IgG2b
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克隆号
1B6
Picture
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Western blot analysis using AKT2 mouse mAb against A431 (1), Jurkat (2), HEK293 (3), A549 (4), MCF-7 (5) and PC-12 (6) cell lysate. |
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Immunofluorescence analysis of PANC-1 (left) and Hela (right) cells using AKT2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. |
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Immunohistochemical analysis of paraffin-embedded human Thymus tissues using anti-AKT2 mAb |
Product Details
Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.
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