Product Information

• 产品货号 BDAF0016
• 别名 Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glycoprotein 80; gp80; CD126
• 产品名称 Recombinant Human IL-6RA (C-Fc)
• 类别 Diagnostic raw materials
• 推荐应用 Dependent by end user
• 存储缓冲液 Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
• Human Swissprot No. P08887
• 参考分子量 85-100kDa, reducing conditions
• 预测分子量 149.2kDa
• 运输及保存条件 Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
• 表达系统 human cells
• 内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• 宿主 human cells
• 背景介绍 Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

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